Proterris is a P2 clinical-stage firm that has pooled a dominant IP position in therapeutic uses of inhaled and small-molecule carbon monoxide. This IP position has been supported by almost 50 preclinical studies and nearly dozen clinical trials, including those supported with ~$23 million in NIH funding to date. The therapeutic indications addressable by both inhaled CO (iCO) and CO-releasing molecules (CORMs) cover a wide range of fibrotic, transplantation, other ischemia-reperfusion injury and anti-inflammatory disorders. Proterris has prioritized CO development in delayed graft function (DGF), acute liver failure, and non-alcoholic steatohepatitis (NASH), with significant opportunities in a number of other indications, including but not limited to acute kidney injury (AKI), renal fibrosis, and idiopathic pulmonary fibrosis (IPF).

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